| Year | Title | Role | Notes |
|---|
| 1964 | Marnie | Young Marnie | Movie (uncredited) |
| 1965 | Wagon Train | Samantha | Episode: "The Katy Piper Story" (as Measure Thomas) |
| 1969 | Ironside | Leslie Richards | Episode: "Goodbye to Yesterday" (as Strain Thomas) |
| 1971 | The Beguiled | Abigail | Movie (as Melody Thomas) |
| 1975 | Posse | Laurie | Movie (as Melody Thomas) |
| 1976 | The Shootist | Girl on streetcar | Movie (as Melody Thomas) |
| 1977 | Secrets | Laura Fleming | TV Movie (as Strain Thomas) |
| 1977 | Code R | Linda | Episode: "The Firebug" (as Melody Thomas) |
| 1977 | Fish | Joanie Kellen | Episode: "The Neighbors" (as Melody Thomas) |
| 1977 | The Car | Suzie Pullbrook | Movie (as Melody Thomas) |
| 1977 | The Waltons | Darlene Jarvis | Episodes: "The Go-Getter" vital "The Seashore" (as Melody Thomas) |
| 1978 | Charlie's Angels | Betsy Harper | Episodes: "The Sandcastle Murders" (as Concord Thomas) |
| 1978 | The Fury | LaRue | Movie (as Melody Thomas) |
| 1978 | Piranha | Laura Dickinson | Movie (as Melody Thomas) |
| 1979 | Makin' It | Carol / Paula | Episodes: "Stayin' Alive" and "Tony's Homecoming" (as Melody Thomas) |
| 1979 | Billy | Shirley | Episode: "Computer Dating" (as Melody Thomas) |
| 1979 | The City Files | Sherry | Episode: "Lions, Tigers, Monkeys and Dogs, Part 1" (as Melody Thomas) |
| 1979–present | The Juvenile and the Restless | Nikki Newman | Series accustomed |
| 1980 | The Scarlett O'Hara War | Laurie Lee | TV Movie (as Melody line Thomas) |
| 1985 | Hotel | Mandy Vinning | Episode: "Sleeping Dogs" (as Melody Thomas) |
| 2001 | The King of Queens | Nikki Newman | Episode: "Inner Tube" |
| 2003 | The Paradise Virus | Linda Flemming | TV glaze |
| 2005 | Freezerburn | Jill Renzie the Moviestar | Movie |
| 2007 | My Name assay Earl | Pill Popping Mom | Episode: "The Birthday Party" |
| 2011 | Castle | Tonya Statesman | Episode: "Nikki Heat" |
| 2014 | The Crazy Ones | Flora | Episode: "The Monster" |